Photodynamic therapy mediated by a red LED and methylene blue inactivates resistant Leishmania amazonensis

article

Autores

Cabral, Fernanda V.

Yoshimura, Tania M.

Teixeira Da Silva, Daniela De Fátima

Cortez, Mauro

Ribeiro, Martha S.

Data de Publicação

1 de maio de 2023

Resumo

Cutaneous leishmaniasis is a neglected parasitic disease that leads to destructive lesions. The emergence of drug resistance has been a global concern over the past years. Photodynamic therapy (PDT) mediated by a red LED and methylene blue (MB) involves the overproduction of oxidative stress, which oxidizes several cellular biomolecules and prevents the selection of resistant strains. Herein, we investigated the potential of PDT mediated by MB against wild-type and miltefosine-resistant strains of Leishmania amazonensis . As a result, both strains were susceptible to PDT, thus encouraging us to seek the best conditions to overcome the drug resistance problem in cutaneous leishmaniasis.

Citação

BibTeX

@online{fernanda_v.2023,
  author = {Fernanda V. , Cabral and Tania M. , Yoshimura and Da Silva,
    Daniela De Fátima, Teixeira and Mauro , Cortez and Martha S. ,
    Ribeiro},
  title = {Photodynamic therapy mediated by a red LED and methylene blue
    inactivates resistant Leishmania amazonensis},
  volume = {40},
  number = {5},
  date = {2023-05-01},
  doi = {10.1364/JOSAA.482314},
  langid = {pt-BR},
  abstract = {Cutaneous leishmaniasis is a neglected parasitic disease
    that leads to destructive lesions. The emergence of drug resistance
    has been a global concern over the past years. Photodynamic therapy
    (PDT) mediated by a red LED and methylene blue (MB) involves the
    overproduction of oxidative stress, which oxidizes several cellular
    biomolecules and prevents the selection of resistant strains.
    Herein, we investigated the potential of PDT mediated by MB against
    wild-type and miltefosine-resistant strains of Leishmania
    amazonensis . As a result, both strains were susceptible to PDT,
    thus encouraging us to seek the best conditions to overcome the drug
    resistance problem in cutaneous leishmaniasis.}
}

Por favor, cite este trabalho como:

Fernanda V., Cabral, Yoshimura Tania M., Teixeira Da Silva, Daniela De Fátima, Cortez Mauro, and Ribeiro Martha S. 2023. “Photodynamic therapy mediated by a red LED and methylene blue inactivates resistant Leishmania amazonensis.” Journal of the Optical Society of America A. May 1, 2023. https://doi.org/10.1364/JOSAA.482314.