Monte Carlo simulations to evaluate geometric variations of a new Iodine-125 seed
Abstract The Nuclear and Energy Research Institute and the National Nuclear Energy Commission (IPEN-CNEN/SP) are developing a new Iodine-125 seed for use in brachytherapy. The manufacturing process includes cutting the titanium tube, welding the ends, and performing leak tests. Seed approval is based on a microscopic analysis of its external geometry. The dosimetric methodology follows Task Group 43 (TG-43), which adopts the Monte Carlo method as the standard simulation technique. However, TG-43 does not account for geometric variations that may occur during the manufacturing process. This study investigated two types of variation: (1) the seed width after welding, and (2) the random positions that the core may assume within the seed. A total of 100 simulations were performed for each variation. The width was measured experimentally using a caliper, after welding, while the core position was modeled using a random number generator, since it is not feasible to measure it directly. These values were used to generate 201 input files for simulations in MCNP 6.2: 100 for each investigated parameter and one for the reference geometry (IPEN-CNEN/SP seed). The results were analyzed using MATLAB through bidimensional matrices of 101 × 101 points. For each point in the matrix, the mean, standard deviation, relative difference (compared to the reference geometry), and Type A uncertainty were calculated. The main results were: a standard deviation of 0.6% and a relative difference of 11% for the seed width; and a standard deviation of 50% and a relative difference of 25% for the core position. The Type A uncertainty was below 0.3% in all cases.
Citação
@online{chico,_henrique_santos2026,
author = {Chico, Henrique Santos, De and Lucas Verdi , Angelocci and
Paula Cristina Guimarães , Antunes and Souza, Carla Daruich, De and
Carlos Alberto , Zeituni and Sabrina Spigaroli , Sgrignoli and Maria
Elisa Chuery Martins , Rostelato},
title = {Monte Carlo simulations to evaluate geometric variations of a
new Iodine-125 seed},
volume = {12},
number = {2},
date = {2026-04-01},
doi = {10.1088/2057-1976/ae43ef},
langid = {pt-BR},
abstract = {Abstract The Nuclear and Energy Research Institute and the
National Nuclear Energy Commission (IPEN-CNEN/SP) are developing a
new Iodine-125 seed for use in brachytherapy. The manufacturing
process includes cutting the titanium tube, welding the ends, and
performing leak tests. Seed approval is based on a microscopic
analysis of its external geometry. The dosimetric methodology
follows Task Group 43 (TG-43), which adopts the Monte Carlo method
as the standard simulation technique. However, TG-43 does not
account for geometric variations that may occur during the
manufacturing process. This study investigated two types of
variation: (1) the seed width after welding, and (2) the random
positions that the core may assume within the seed. A total of 100
simulations were performed for each variation. The width was
measured experimentally using a caliper, after welding, while the
core position was modeled using a random number generator, since it
is not feasible to measure it directly. These values were used to
generate 201 input files for simulations in MCNP 6.2: 100 for each
investigated parameter and one for the reference geometry
(IPEN-CNEN/SP seed). The results were analyzed using MATLAB through
bidimensional matrices of 101~×~101 points. For each point in the
matrix, the mean, standard deviation, relative difference (compared
to the reference geometry), and Type A uncertainty were calculated.
The main results were: a standard deviation of 0.6\% and a relative
difference of 11\% for the seed width; and a standard deviation of
50\% and a relative difference of 25\% for the core position. The
Type A uncertainty was below 0.3\% in all cases.}
}