Profile of MicroRNAs Associated with Death Due to Disease Progression in Metastatic Papillary Thyroid Carcinoma Patients
Papillary thyroid carcinoma (PTC) is the most common neoplasm of the endocrine system and has an excellent long-term prognosis, with low rates of distant metastatic disease. Although infrequent, there are cases of deaths directly related to PTC, especially in patients with metastatic disease, and the factors that could be associated with this unfavorable outcome remain a major challenge in clinical practice. Recently, research into genetic factors associated with PTC has gained ground, especially mutations in the TERT promoter and BRAF gene. However, the role of microRNAs remains poorly studied, especially in those patients who have an unfavorable outcome at follow-up. This paper aims to evaluate molecular markers related to the different pathological processes of PTC, as well as the histological characteristics of the neoplasm, and to compare this profile with prognosis and death from the disease using an analysis of patients treated for metastatic disease in a single tertiary cancer center. Evaluation of microRNA expression in paraffin-embedded tumor specimens was carried out by quantitative PCR using the TaqMan® Low Density Array (TLDA) system. Metastatic patients who died from progression of PTC had higher expressions of miR-101-3p, miR-17-5p, and miR-191-5p when compared to patients with stable metastatic disease. These findings are of great importance but should be considered as preliminary because of the small sample.
Citação
@online{ana_kober2023,
author = {Ana Kober , Leite and Kelly Cristina , Saito and Thérèse
Rachell , Theodoro and Fátima Solange , Pasini and Luana Perrone ,
Camilo and Carlos Augusto , Rossetti and Beatriz Godoi , Cavalheiro
and Venâncio Avancini Ferreira , Alves and Luiz Paulo , Kowalski and
Maria Aparecida Silva , Pinhal and Edna Teruko , Kimura and Leandro
Luongo , Matos},
title = {Profile of MicroRNAs Associated with Death Due to Disease
Progression in Metastatic Papillary Thyroid Carcinoma Patients},
volume = {15},
number = {3},
date = {2023-01-31},
doi = {10.3390/cancers15030869},
langid = {pt-BR},
abstract = {Papillary thyroid carcinoma (PTC) is the most common
neoplasm of the endocrine system and has an excellent long-term
prognosis, with low rates of distant metastatic disease. Although
infrequent, there are cases of deaths directly related to PTC,
especially in patients with metastatic disease, and the factors that
could be associated with this unfavorable outcome remain a major
challenge in clinical practice. Recently, research into genetic
factors associated with PTC has gained ground, especially mutations
in the TERT promoter and BRAF gene. However, the role of microRNAs
remains poorly studied, especially in those patients who have an
unfavorable outcome at follow-up. This paper aims to evaluate
molecular markers related to the different pathological processes of
PTC, as well as the histological characteristics of the neoplasm,
and to compare this profile with prognosis and death from the
disease using an analysis of patients treated for metastatic disease
in a single tertiary cancer center. Evaluation of microRNA
expression in paraffin-embedded tumor specimens was carried out by
quantitative PCR using the TaqMan® Low Density Array (TLDA) system.
Metastatic patients who died from progression of PTC had higher
expressions of miR-101-3p, miR-17-5p, and miR-191-5p when compared
to patients with stable metastatic disease. These findings are of
great importance but should be considered as preliminary because of
the small sample.}
}